Business and Information System Alignment Theories Built on eGovernment Service Practice: An Holistic Literature Review

© 2019 The Author(s). Licensee IntechOpen. This chapter is distributed under the terms of the Creative Commons Attribution 3.0 License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.This chapter examines previous studies of alignment between business and information systems holistically in relation to the development of working associations among professionals from information system and business backgrounds in business organization and eGovernment sectors while investigating alignment research that permits the development and growth of information system, which is appropriate, within budget and on-time development. The process of alignment plays a key role in the construction of dependent associations among individuals from two different groups, and the progress of alignment could be enhanced by emerging an information system according to the investors’ prospects. The chapter presents system theory to gather and analyze the data across the designated platforms. The outcomes classify that alignment among business and information system departments remains a priority and is of worry in different ways in diverse areas, which provides prospects for the forthcoming discussion and research.Final Published versio

Investigation of eGovernment Services and Alignment between Business and Information Systems

Inhabitant’s implementation of eGovernment services is a key objective for the Government of developed and developing countries. However, to improve the eGovernment services it is important for any Government to align all stakeholders so that the needs of citizens can be examined and addressed. This paper proposed a framework of an ideal pattern of alignment for the Government of Saudi Arabia. The framework has been validated empirically and the result indicates that the Government of Saudi Arabia is spending a huge amount of budget to improve the Government services, but still many services are slow and are not as per expectations. Therefore, citizens of KSA recommended alignment between eGovernment agencies and IS department.Final Accepted Versio

Identification of current IS challenges based on the business/IS alignment model and improving eGovernment services

Information systems (IS) are currently used in various units of the eGovernment sector in order to improve the efficiency, quality, usefulness, rapidity and convenience of their services or products. However, not all governments are able to benefit from the full advantages of IS development due to a lack of alignment between the IS department and other agencies in the eGovernment sector. There is no common framework or model that can be applied globally. Each country develops its own eGovernment programmes based on its needs and other national considerations such as political, economic, cultural and social factors. The literature indicates that eGovernment adoption, uses and development have been considered extensively from the viewpoints of the organization and technical issues. However, there is a need for further investigation to inspect how eGovernment agencies can be aligned so that the efficiency of their services can be improved. A strong alignment not only assists any government in improving the performance of its services, but it also enhances public trust in the government’s services. The concept of alignment is not new, first emerging in the 1970s. Since then, researchers and practitioners have studied the process of alignment in the context of organizational strategic alignment, structural and business goals alignment. This thesis proposes an ideal pattern of alignment for the eGovernment sector in the Kingdom of Saudi Arabia and proposes modelling IS requirements as a suitable solution for strong alignment. The ideal pattern of alignment consists of strategic, structural, social and cultural alignment between the IS department and other agencies in the eGovernment sector. The study uses a mixed (qualitative and quantitative) method approach to validate the proposed ideal pattern of alignment. For the qualitative study, initially the factors affecting the ideal pattern of alignment are extracted from the literature and validated by the eGovernment experts. The qualitative data were collected from 20 eGovernment experts from different eGovernment sectors in the Kingdom of Saudi Arabia. The thematic analysis approach is identified as a suitable approach to analyse qualitative data. For the quantitative study, the questionnaire was posted online and possible participants were contacted in the Saudi ministry. The data were collected from 200 eGovernment users in Saudi Arabia. To analyse the quantitative data, confirmatory factor analysis and structural equation model approaches are used. At the process modelling phase, a case study on patient visits to a healthcare clinic is used to validate the method of modelling IS requirements in the context of eGovernment alignment. The study results indicate: 1) if the eGovernment sector in Saudi Arabia is aligned through this ideal pattern of alignment, improved eGovernment performance and enhanced public trust can be achieved; 2) the eGovernment sector in Saudi Arabia can improve its internal and external relations by focusing on the ideal pattern of alignment; 3) modelling and analysing the government environment have a positive impact on the implementation of IS which meets the needs of the government and consequently positively affects the process of alignment

<i>Helicobacter pylori</i> Infection: Current Status and Future Prospects on Diagnostic, Therapeutic and Control Challenges

Helicobacter pylori (H. pylori) infection, which affects approximately half of the world’s population, remains a serious public health problem. As H. pylori infection leads to a number of gastric pathologies, including inflammation, gastroduodenal ulcers, and malignancies, early detection and treatment are crucial to preventing the spread of the infection. Multiple extragastric complications, such as iron deficiency anaemia, immune thrombocytopenic purpura, vitamin B12 deficiency, diabetes mellitus, cardiovascular diseases, and certain neurological disorders, have also been linked to H. pylori infection. An awareness of H. pylori and associated health hazards is necessary to minimize or even eradicate the infection. Therefore, there is an urgent need to raise the standards for the currently employed diagnostic, eradication, alternative treatment strategies. In addition, a brief overview of traditional and cutting-edge approaches that have proven effective in identifying and managing H. pylori is needed. Based on the test and laboratory equipment available and patient clinical characteristics, the optimal diagnostic approach requires weighing several factors. The pathophysiology and pathogenic mechanisms of H. pylori should also be studied, focusing more on the infection-causing virulence factors of this bacterium. Accordingly, this review aims to demonstrate the various diagnostic, pathophysiological, therapeutic, and eradication tactics available for H. pylori, emphasizing both their advantages and disadvantages. Invasive methods (such as quick urease testing, biopsy, or culture) or noninvasive methods (such as breath tests, stool investigations, or serological tests) can be used. We also present the most recent worldwide recommendations along with scientific evidence for treating H. pylori. In addition to the current antibiotic regimens, alternative therapies may also be considered. It is imperative to eradicate the infections caused by H. pylori as soon as possible to prevent problems and the development of stomach cancer. In conclusion, significant advances have been made in identifying and treating H. pylori. To improve eradication rates, peptide mass fingerprinting can be used as a diagnostic tool, and vaccines can also eliminate the infection

Helicobacter pylori Infection: Current Status and Future Prospects on Diagnostic, Therapeutic and Control Challenges

Helicobacter pylori (H. pylori) infection, which affects approximately half of the world&rsquo;s population, remains a serious public health problem. As H. pylori infection leads to a number of gastric pathologies, including inflammation, gastroduodenal ulcers, and malignancies, early detection and treatment are crucial to preventing the spread of the infection. Multiple extragastric complications, such as iron deficiency anaemia, immune thrombocytopenic purpura, vitamin B12 deficiency, diabetes mellitus, cardiovascular diseases, and certain neurological disorders, have also been linked to H. pylori infection. An awareness of H. pylori and associated health hazards is necessary to minimize or even eradicate the infection. Therefore, there is an urgent need to raise the standards for the currently employed diagnostic, eradication, alternative treatment strategies. In addition, a brief overview of traditional and cutting-edge approaches that have proven effective in identifying and managing H. pylori is needed. Based on the test and laboratory equipment available and patient clinical characteristics, the optimal diagnostic approach requires weighing several factors. The pathophysiology and pathogenic mechanisms of H. pylori should also be studied, focusing more on the infection-causing virulence factors of this bacterium. Accordingly, this review aims to demonstrate the various diagnostic, pathophysiological, therapeutic, and eradication tactics available for H. pylori, emphasizing both their advantages and disadvantages. Invasive methods (such as quick urease testing, biopsy, or culture) or noninvasive methods (such as breath tests, stool investigations, or serological tests) can be used. We also present the most recent worldwide recommendations along with scientific evidence for treating H. pylori. In addition to the current antibiotic regimens, alternative therapies may also be considered. It is imperative to eradicate the infections caused by H. pylori as soon as possible to prevent problems and the development of stomach cancer. In conclusion, significant advances have been made in identifying and treating H. pylori. To improve eradication rates, peptide mass fingerprinting can be used as a diagnostic tool, and vaccines can also eliminate the infection

Biallelic variants in COPB1 cause a novel, severe intellectual disability syndrome with cataracts and variable microcephaly.

BACKGROUND: Coat protein complex 1 (COPI) is integral in the sorting and retrograde trafficking of proteins and lipids from the Golgi apparatus to the endoplasmic reticulum (ER). In recent years, coat proteins have been implicated in human diseases known collectively as "coatopathies". METHODS: Whole exome or genome sequencing of two families with a neuro-developmental syndrome, variable microcephaly and cataracts revealed biallelic variants in COPB1, which encodes the beta-subunit of COPI (?-COP). To investigate Family 1's splice donor site variant, we undertook patient blood RNA studies and CRISPR/Cas9 modelling of this variant in a homologous region of the Xenopus tropicalis genome. To investigate Family 2's missense variant, we studied cellular phenotypes of human retinal epithelium and embryonic kidney cell lines transfected with a COPB1 expression vector into which we had introduced Family 2's mutation. RESULTS: We present a new recessive coatopathy typified by severe developmental delay and cataracts and variable microcephaly. A homozygous splice donor site variant in Family 1 results in two aberrant transcripts, one of which causes skipping of exon 8 in COPB1 pre-mRNA, and a 36 amino acid in-frame deletion, resulting in the loss of a motif at a small interaction interface between ?-COP and ?'-COP. Xenopus tropicalis animals with a homologous mutation, introduced by CRISPR/Cas9 genome editing, recapitulate features of the human syndrome including microcephaly and cataracts. In vitro modelling of the COPB1 c.1651T>G p.Phe551Val variant in Family 2 identifies defective Golgi to ER recycling of this mutant ?-COP, with the mutant protein being retarded in the Golgi. CONCLUSIONS: This adds to the growing body of evidence that COPI subunits are essential in brain development and human health and underlines the utility of exome and genome sequencing coupled with Xenopus tropicalis CRISPR/Cas modelling for the identification and characterisation of novel rare disease genes.The article is available via Open Access. Click on the 'Additional link' above to access the full-text.Published version, accepted versio